Water → HCID 59633913、化合物

HRID 1615061ノート

反応式

HRID 1615061 の反応式
[I:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([O:9][CH3:10])[CH:3]=1.C([O-])([O-])=O.[K+].[K+].[CH2:17]([C:19]1[CH:26]=[CH:25][C:22]([CH2:23]Cl)=[CH:21][CH:20]=1)[CH3:18].O>CN(C=O)C>[CH2:17]([C:19]1[CH:26]=[CH:25][C:22]([CH2:23][O:8][C:5]2[CH:6]=[CH:7][C:2]([I:1])=[CH:3][C:4]=2[O:9][CH3:10])=[CH:21][CH:20]=1)[CH3:18]

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 738434-Ethylbenzyl chlorideHCID 101061274-Iodo-2-methoxyphenol

生成物 1

HCID 59633913HCID 59633913、化合物収率 87%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
80 °C

実験手順

To a solution of 4-iodo-2-methoxyphenol (90 g) in DMF (450 mL) were added K2CO3 (60 g) and 4-ethylbenzyl chloride (58 g) at RT. The reaction mixture was stirred at 80° C. for 3 hr. Water (900 mL) was added to the reaction mixture. The precipitated solid was collected on a filter and dried under reduced pressure. The suspension of this solid in heptane (520 mL) was stirred at RT. The precipitated solid was collected on a filter and dried under reduced pressure to give the title compound (115 g, 87%).

後処理

  1. customThe precipitated solid was collected on
  2. filtrationa filter
  3. customdried under reduced pressure
  4. additionThe suspension of this solid in heptane (520 mL)
  5. stirringwas stirred at RT
  6. customThe precipitated solid was collected on
  7. filtrationa filter
  8. customdried under reduced pressure

出典と根拠

ORDレコード
ord-b974f25500f94a3a8049a6ef4e19be96
出典データセット
uspto-grants-2014_07
特許番号
US08765739B2

反応ノート

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