(S)-1-(4-(Trifluoromethoxy)phenyl)ethanamine → 3,3-Dimethyl-9-{2-[(S)-1-(4-trifluoromethoxy-phenyl)-ethylamino]-ethyl}-1,5-dioxa-spiro[5.5]undecan-9-ol

HRID 1615133ノート

反応式

HRID 1615133 の反応式
[OH:1][C:2]1([CH2:15][CH:16]=O)[CH2:14][CH2:13][C:5]2([O:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7][O:6]2)[CH2:4][CH2:3]1.[F:18][C:19]([F:31])([F:30])[O:20][C:21]1[CH:26]=[CH:25][C:24]([C@@H:27]([NH2:29])[CH3:28])=[CH:23][CH:22]=1>>[CH3:12][C:8]1([CH3:11])[CH2:9][O:10][C:5]2([CH2:13][CH2:14][C:2]([CH2:15][CH2:16][NH:29][C@H:27]([C:24]3[CH:23]=[CH:22][C:21]([O:20][C:19]([F:18])([F:30])[F:31])=[CH:26][CH:25]=3)[CH3:28])([OH:1])[CH2:3][CH2:4]2)[O:6][CH2:7]1

参加物

3

反応物 2

HCID 40786949(S)-1-(4-(Trifluoromethoxy)phenyl)ethanamineHCID 86668369(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde

生成物 1

HCID 679962903,3-Dimethyl-9-{2-[(S)-1-(4-trifluoromethoxy-phenyl)-ethylamino]-ethyl}-1,5-dioxa-spiro[5.5]undecan-9-ol収率 52%

実験手順

The title compound is prepared from (9-hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde and (S)-1-(4-trifluoromethoxy-phenyl)-ethylamine following a procedure analogous to that described in Step 3 of Intermediate 2. Yield: 52% of theory; LC (method 5): tR=1.13 min; Mass spectrum (ESI+): m/z=432 [M+H]+.

出典と根拠

ORDレコード
ord-fdbec25527144838907a68e721dc8647
出典データセット
uspto-grants-2014_07
特許番号
US08765744B2

反応ノート

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