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(S)-1-(3,4-Difluorophenyl)ethanamine → 9-{2-[(S)-1-(3,4-Difluoro-phenyl)-ethylamino]-ethyl}-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecan-9-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (S)-1-(3,4-Difluorophenyl)ethanamine | HCID 7016601 | — |
| 反応物 | (9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde | HCID 86668369 | — |
| 生成物 | 9-{2-[(S)-1-(3,4-Difluoro-phenyl)-ethylamino]-ethyl}-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecan-9-ol | HCID 67996346 | 54% |
反応手順
The title compound is prepared from (9-hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde and (S)-1-(3,4-difluoro-phenyl)-ethylamine following a procedure analogous to that described in Step 3 of Intermediate 2. Yield: 54% of theory; LC (method 5): tR=1.00 min; Mass spectrum (ESI+): m/z=384 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08765744B2 |
| 出典データセット | uspto-grants-2014_07 |
| ORD ID | ord-92ea6f01d08c4452b87939a77e7e051e |
| 出典メモ | uspto-grants-2014_07 |