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Dimethylsulphamoyl chloride → N,N-dimethyl-N'-(2-oxo-2,3-dihydro-1H-indol-5-yl)sulfamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylsulphamoyl chloride | HCID 83372 | — |
| 反応物 | 5-Amino-2-oxindole | HCID 2773213 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | N,N-dimethylformamide ethyl acetate | HCID 22989253 | — |
| 生成物 | N,N-dimethyl-N'-(2-oxo-2,3-dihydro-1H-indol-5-yl)sulfamide | HCID 69812379 | 32.3% |
反応手順
To 5-aminoindolin-2-one (100 mg, 0.68 mmol) in ethyl acetate/DMF 1:1 (2 mL) was added dimethylsulfamoyl chloride (290 mg, 2.04 mmol) and DMAP (1 mg). After 72 h the product was precipitated with ether, filtered and dried to give 56 mg, 32% of a white solid. 1H NMR (400 MHz, CD3OD) δ 7.21 (s, 1H), 7.16 (d, J=7.0 Hz, 1H), 7.00 (d, J=8.0 Hz, 1H), 3.53 (s, 2H), 2.77 (s, 6H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08765748B2 |
| 出典データセット | uspto-grants-2014_07 |
| ORD ID | ord-9de4efba5023491ca359db0caef9324f |
| 出典メモ | uspto-grants-2014_07 |