関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | 2,5-Dimethylpyrazine | HCID 31252 | — |
| 反応物 | O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine | HCID 11830845 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-Amino-2,5-dimethylpyrazin-1-ium 2,4,6-trimethylbenzenesulfonate | HCID 12633433 | 97.1% |
反応手順
A solution of 2,5-dimethylpyrazine (3.24 g, 30.0 mmol) in dichloromethane (DCM) (30 mL) was cooled to 0° C. A solution of O-(mesitylsulfonyl)hydroxylamine (12.9 g, 60.0 mmol) in DCM (30 mL) was added. The mixture was stirred at 0° C. for 1 h. Then diethyl ether (Et2O) (150 mL) was added. The precipitate was filtered and collected to give 9.42 g (97% yield) of the title compound as a white solid. ESI MS: m/z 124.1 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08765760B2 |
|---|
| 出典データセット | uspto-grants-2014_07 |
|---|
| ORD ID | ord-b7584066f8014bd896a0e37825780d6c |
|---|
| 出典メモ | uspto-grants-2014_07 |
|---|
