HCID 68089188、化合物 → HCID 86667806、化合物
反応式
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]3[CH:10]=[CH:11][CH:12]=[N:13][C:14]=3[C:5]=2[N:4]=[C:3]1[CH2:15][OH:16]>C(Cl)Cl.[O-2].[Mn+4].[O-2]>[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]3[CH:10]=[CH:11][CH:12]=[N:13][C:14]=3[C:5]=2[N:4]=[C:3]1[CH:15]=[O:16]参加物
4
実験手順
To a solution of (3-methyl-3H-imidazo[4,5-h]quinolin-2-yl)methanol (560 mg, 2.62 mmol) in DCM (10 mL) was added manganese (IV) oxide (2.28 g, 26.2 mmol). The mixture was stirred at room temperature for 12 h. The solid was removed by filtration and the filtrate was concentrated. The crude product was purified by silica gel column chromatography (eluting with PE/EtOAc v/v 2:1) to give 3-methyl-3H-imidazo[4,5-h]quinoline-2-carbaldehyde as a yellow solid (370 mg, yield: 67.5%). ESI MS: m/z 212 [M+H]+.
後処理
- customThe solid was removed by filtration
- concentrationthe filtrate was concentrated
- customThe crude product was purified by silica gel column chromatography (
- washeluting with PE/EtOAc v/v 2:1)
出典と根拠
- ORDレコード
- ord-3cf5f07bf2304651a7a45c342903e333
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08765760B2
反応ノート
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