Glyoxal → Quinoxaline, 6-nitro-

HRID 1615638

反応式

HRID 1615638 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([NH2:11])[C:7]([NH2:10])=[CH:8][CH:9]=1)([O-:3])=[O:2].[CH:12](=O)[CH:13]=O>CCO>[N+:1]([C:4]1[CH:5]=[C:6]2[C:7](=[CH:8][CH:9]=1)[N:10]=[CH:13][CH:12]=[N:11]2)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 7860GlyoxalHCID 51117914-Nitro-1,2-phenylenediamine

生成物 1

HCID 96029Quinoxaline, 6-nitro-収率 97.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A suspension of 4-nitrobenzene-1,2-diamine (15.3 g, 0.1 mol) and oxalaldehyde (40% in water, 17.4 g, 0.12 mol) in EtOH (150 mL) was stirred at reflux for 16 h. The mixture was then filtered, and the solid was collected to give 6-nitroquinoxaline as a yellow solid (17.0 g, yield 97%). ESI MS: m/z 176.0 [M+H]+.

後処理

  1. temperatureat reflux for 16 h
  2. filtrationThe mixture was then filtered
  3. customthe solid was collected

出典と根拠

ORDレコード
ord-6ef8dccfe38c4057b44168e7334c479d
出典データセット
uspto-grants-2014_07
特許番号
US08765760B2

関連ノート

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