Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → 2-(3-(4-fluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)-N-((R)-2'-oxo-1,1',2',3-tetrahydrospiro[inden-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)acetamide

HRID 1615754ノート

反応式

HRID 1615754 の反応式
C(OC([N:8]1[C:13]2([CH2:19][O:18][CH2:17][CH2:16][O:15][CH2:14]2)[C:12](=[O:20])[N:11]([CH2:21][C:22]([OH:24])=O)[CH:10]([C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)[CH2:9]1)=O)(C)(C)C.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[NH2:56][C:57]1[CH:58]=[C:59]2[C:72](=[CH:73][CH:74]=1)[CH2:71][C@@:61]1([C:69]3[C:64](=[N:65][CH:66]=[CH:67][CH:68]=3)[NH:63][C:62]1=[O:70])[CH2:60]2>CN(C=O)C>[F:31][C:28]1[CH:29]=[CH:30][C:25]([CH:10]2[N:11]([CH2:21][C:22]([NH:56][C:57]3[CH:58]=[C:59]4[C:72](=[CH:73][CH:74]=3)[CH2:71][C@:61]3([C:69]5[C:64](=[N:65][CH:66]=[CH:67][CH:68]=5)[NH:63][C:62]3=[O:70])[CH2:60]4)=[O:24])[C:12](=[O:20])[C:13]3([CH2:19][O:18][CH2:17][CH2:16][O:15][CH2:14]3)[NH:8][CH2:9]2)=[CH:26][CH:27]=1

参加物

5

反応物 3

HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 54776259(S)-5-amino-1,3-dihydrospiro[indene-2,3-pyrrolo[2,3-b]pyridin]-2(1H)-oneHCID 681545962-(1-(Tert-butoxycarbonyl)-3-(4-fluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)ethanoic acid

生成物 1

HCID 681542852-(3-(4-fluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)-N-((R)-2'-oxo-1,1',2',3-tetrahydrospiro[inden-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)acetamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

0.26 g (0.6 mmol) 2-(1-(tert-butoxycarbonyl)-3-(4-fluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)ethanoic acid in 10 ml DMF were combined with 0.46 g (1.2 mmol) HATU and 0.20 ml (1.4 mmol) TEA and stirred for 10 min at RT. Then 0.17 g (0.66 mmol) (S)-5-amino-1,3-dihydrospiro[inden-2,3′-pyrrolo[2,3-b]pyridin]-2′(1′H)-one were added and the mixture was stirred overnight at RT. The reaction mixture was poured onto water. The precipitate formed was suction filtered, washed with water and dried.

後処理

  1. stirringthe mixture was stirred overnight at RT
  2. additionThe reaction mixture was poured onto water
  3. customThe precipitate formed
  4. filtrationfiltered
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-2ddbce5639bc4be982c9abb27dfd5d11
出典データセット
uspto-grants-2014_07
特許番号
US08765763B2

反応ノート

読み込み中…