Hydrochloric Acid → (R)-methyl 2-(3-(3,5-difluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)acetate hydrochloride

反応式

[F:1][C:2]1[CH:3]=[C:4]([C@H:9]2[N:14]([CH2:15][C:16]([O:18][CH3:19])=[O:17])[C:13](=[O:20])[C:12]3([CH2:26][O:25][CH2:24][CH2:23][O:22][CH2:21]3)[N:11](C(OC(C)(C)C)=O)[CH2:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1.[ClH:34]>>[ClH:34].[F:8][C:6]1[CH:5]=[C:4]([C@H:9]2[N:14]([CH2:15][C:16]([O:18][CH3:19])=[O:17])[C:13](=[O:20])[C:12]3([CH2:21][O:22][CH2:23][CH2:24][O:25][CH2:26]3)[NH:11][CH2:10]2)[CH:3]=[C:2]([F:1])[CH:7]=1

参加物

反応物 2

HCID 313Hydrochloric Acid

HCID 68154574tert-butyl (R)-3-(3,5-difluoro-phenyl)-4-methoxycarbonylmethyl-5-oxo-8,11-dioxa-1,4-diaza-spiro[5.6]dodecane-1-carboxylate

生成物 1

HCID 68154674(R)-methyl 2-(3-(3,5-difluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)acetate hydrochloride

反応条件

温度: 50 °C

実験手順

0.13 g (0.28 mmol) tert-butyl (R)-3-(3,5-difluoro-phenyl)-4-methoxycarbonylmethyl-5-oxo-8,11-dioxa-1,4-diaza-spiro[5.6]dodecane-1-carboxylate were combined with 20 ml of a 1M methanolic hydrochloric acid solution and stirred for 2 h at 50° C. The reaction mixture was concentrated by rotary evaporation and further reacted without any further purification.

後処理

concentrationThe reaction mixture was concentrated by rotary evaporation
customfurther reacted without any further purification

出典と根拠

ORDレコード: ord-f635bd57fb15454dbdaabded8c7ea9e0
出典データセット: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08765763B2

反応ノート

読み込み中…