Hydrazine → N-aminobenzenecarbothioamide

HRID 1616552

反応式

HRID 1616552 の反応式
COC(=O)C[S:5][C:6](=S)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[NH2:15][NH2:16]>C(O)C>[C:6]([NH:15][NH2:16])(=[S:5])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

参加物

4

反応物 2

HCID 9321HydrazineHCID 71356278Methyl 2-((phenylcarbonothioyl)thio)acetate

生成物 1

HCID 3361911N-aminobenzenecarbothioamide収率 94%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Add a solution of thiobenzoylsulfanylacetic acid methyl ester (1.9 g, 8.4 mmol) in ethanol (30 mL) to a solution of anhydrous hydrazine (1 mL) at room temperature under nitrogen and stir for 2 hours. Then add water (20 mL) and remove the solvent under reduced pressure. Dissolve the residue in ethyl acetate (300 mL), wash with water (200 mL) and brine (200 mL), and dry over magnesium sulfate. Remove the solvent under reduced pressure to provide thiobenzoic acid hydrazide (1.2 g, 94%).

後処理

  1. customThen add water (20 mL) and remove the solvent under reduced pressure
  2. dissolutionDissolve the residue in ethyl acetate (300 mL)
  3. washwash with water (200 mL) and brine (200 mL)
  4. dry with materialdry over magnesium sulfate
  5. customRemove the solvent under reduced pressure

出典と根拠

ORDレコード
ord-ba5d82d32f0e4da5af7db1d74368ee13
出典データセット
uspto-grants-2014_07
特許番号
US08765796B2

関連ノート

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