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HRID 1616925作成日：2026年10月27日

2'-Hydroxy-3'-methoxyacetophenone → tert-butyl 6-hydroxy-4a-methyl-3,4,4a,9a-tetrahydro[1]benzofuro[2,3-c]pyridine-2(1H)-carboxylate

https://huagongshe.com/reaction/1616925

反応式

関与物質

役割名称HCID仕込み量
反応物2'-Hydroxy-3'-methoxyacetophenoneHCID 95993—
反応物Tert-butyl 7-hydroxy-4a-methyl-3,4,4a,9a-tetrahydro[1]benzofuro[2,3-c]pyridine-2(1H)-carboxylateHCID 68304817—
生成物tert-butyl 6-hydroxy-4a-methyl-3,4,4a,9a-tetrahydro[1]benzofuro[2,3-c]pyridine-2(1H)-carboxylateHCID 68304691—

反応手順

Synthesized as described for tert-butyl 7-hydroxy-4a-methyl-3,4,4a,9a-tetrahydro[1]benzofuro[2,3-c]pyridine-2(1H)-carboxylate and as described in J. Med. Chem., 1989, 32, 2221-2226 starting from 1-(2-hydroxy-3-methoxyphenyl)-ethanone. MS m/z 250 [M-tBu+H]+

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08765779B2
出典データセットuspto-grants-2014_07
ORD IDord-aa31bad2a93b43c88cd7ae72556ca5c1
出典メモuspto-grants-2014_07