関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 2-Bromopropane | HCID 6358 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 5-Iodobenzene-1,3-diol | HCID 616755 | — |
| 生成物 | 3-Iodo-5-isopropoxyphenol | HCID 67325346 | 37.8% |
反応手順
A mixture of 5-Iodo-benzene-1,3-diol (2 g, 8 mmol), 2-bromopropane (0.88 mL, 9.3 mmol) and potassium carbonate (1.3 g, 9.3 mmol) in DMF (15 mL, 190 mmol) was stirred at 65° C. After 18 h, the mixture was cooled to RT and the solvent was evaporated. The residue was dissolved in DCM, washed with water and brine. The solvent was evaporated and the residue was purified on silica gel using an ISCO instrument and eluting with hexanes:EtOAc (4:1) to afford the title product (841 mg). MS m/z: 279 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08765779B2 |
|---|
| 出典データセット | uspto-grants-2014_07 |
|---|
| ORD ID | ord-26b89431d05b4ac4a031f081e8aa30ca |
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| 出典メモ | uspto-grants-2014_07 |
|---|
