(S)-3-aminoheptan-1-ol → (S)-tert-Butyl 3-(2-amino-4-(1-hydroxyheptan-3-ylamino)-6-methylpyrimidin-5-yl)prop-2-ynylcarbamate

HRID 1617140ノート

反応式

HRID 1617140 の反応式
[NH2:1][C:2]1[N:7]=[C:6](Cl)[C:5]([C:9]#[C:10][CH2:11][NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[C:4]([CH3:20])[N:3]=1.[NH2:21][C@@H:22]([CH2:26][CH2:27][CH2:28][CH3:29])[CH2:23][CH2:24][OH:25]>C(O)CCC>[NH2:1][C:2]1[N:7]=[C:6]([NH:21][C@@H:22]([CH2:26][CH2:27][CH2:28][CH3:29])[CH2:23][CH2:24][OH:25])[C:5]([C:9]#[C:10][CH2:11][NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[C:4]([CH3:20])[N:3]=1

参加物

4

反応物 2

HCID 55290391(S)-3-aminoheptan-1-olHCID 86633394tert-Butyl 3-(2-amino-4-chloro-6-methylpyrimidin-5-yl)prop-2-ynylcarbamate

生成物 1

HCID 86633395(S)-tert-Butyl 3-(2-amino-4-(1-hydroxyheptan-3-ylamino)-6-methylpyrimidin-5-yl)prop-2-ynylcarbamate収率 64.4%

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

The product from step (vi) (200 mg) and the product from step (v) (177 mg) were combined in butan-1-ol (5 mL) and reacted in a CEM Microwave, at 120° C. for 1 h. The solvents were evaporated, and the crude product was purified by chromatography, eluting with 5% MeOH in EtOAc to afford the subtitle compound 170 mg.

後処理

  1. customreacted in a CEM Microwave, at 120° C. for 1 h
  2. customThe solvents were evaporated
  3. customthe crude product was purified by chromatography
  4. washeluting with 5% MeOH in EtOAc

出典と根拠

ORDレコード
ord-c83d8d4b57d643f7827f3c42838cf8d2
出典データセット
uspto-grants-2014_07
特許番号
US08765939B2

反応ノート

読み込み中…