Hydrochloric Acid → Methyl 2-(4-(2-(3-(2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)propylamino)-2-oxoethyl)phenyl)acetate

HRID 1617169ノート

反応式

HRID 1617169 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][CH2:10][CH2:11][NH:12][C:13](=[O:25])[CH2:14][C:15]2[CH:20]=[CH:19][C:18]([CH2:21][C:22]([OH:24])=[O:23])=[CH:17][CH:16]=2)=[C:4]([NH:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[N:3]=1.Cl.[CH3:33]O>O1CCOCC1>[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][CH2:10][CH2:11][NH:12][C:13](=[O:25])[CH2:14][C:15]2[CH:20]=[CH:19][C:18]([CH2:21][C:22]([O:24][CH3:33])=[O:23])=[CH:17][CH:16]=2)=[C:4]([NH:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[N:3]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 68415389{4-[2-({3-[2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl]propyl}amino)-2-oxoethyl]phenyl}acetic acid

生成物 1

HCID 42613075Methyl 2-(4-(2-(3-(2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)propylamino)-2-oxoethyl)phenyl)acetate

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

The product from step (i) was dissolved in MeOH (20 mL) then a solution of HCl in dioxane (4M, 0.3 ml) was added and stirred overnight. Solvent was removed and the residue purified by RPHPLC to afford the title compound, 0.032 g.

後処理

  1. customSolvent was removed
  2. customthe residue purified by RPHPLC

出典と根拠

ORDレコード
ord-3864013422a146228a2f5026f75792b8
出典データセット
uspto-grants-2014_07
特許番号
US08765939B2

反応ノート

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