Potassium Cyanide → 2-(4-((2-Amino-4-chloro-6-methylpyrimidin-5-yl)methyl)-3-fluorophenyl)acetonitrile

HRID 1617181

反応式

HRID 1617181 の反応式
[C-:1]#[N:2].[K+].[Cl:4][C:5]1[C:10]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18]Cl)=[CH:14][C:13]=2[F:20])=[C:9]([CH3:21])[N:8]=[C:7]([NH2:22])[N:6]=1>CS(C)=O.CN(C=O)C.CCOC(C)=O>[NH2:22][C:7]1[N:6]=[C:5]([Cl:4])[C:10]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18][C:1]#[N:2])=[CH:14][C:13]=2[F:20])=[C:9]([CH3:21])[N:8]=1

参加物

6

反応物 2

HCID 9032Potassium CyanideHCID 866334044-Chloro-5-(4-(chloromethyl)-2-fluorobenzyl)-6-methylpyrimidin-2-amine

生成物 1

HCID 866334052-(4-((2-Amino-4-chloro-6-methylpyrimidin-5-yl)methyl)-3-fluorophenyl)acetonitrile

試薬・触媒・溶媒 3

HCID 679Dimethyl Sulfoxide溶媒HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

Potassium cyanide (0.056 g) was added to a stirred solution of the product from step (ii) (0.13 g) in DMSO (imL) and DMF (1 mL). The mixture was stirred at rt for 15 h and then diluted with EtOAc (10 mL). The organic phase was washed with water and brine then dried, filtered and evaporated to give the subtitle compound, 0.12 g.

後処理

  1. washThe organic phase was washed with water and brine
  2. customthen dried
  3. filtrationfiltered
  4. customevaporated

出典と根拠

ORDレコード
ord-4c879e1283e440e6b9a638489cfc5533
出典データセット
uspto-grants-2014_07
特許番号
US08765939B2

関連ノート

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