Potassium Cyanide → HCID 178433372、化合物

HRID 1617205ノート

反応式

HRID 1617205 の反応式
[C-:1]#[N:2].[K+].Cl.[NH2:5][C:6]1[N:11]=[C:10]([OH:12])[C:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20]Cl)=[CH:16][CH:15]=2)=[C:8]([CH3:22])[N:7]=1>CN(C=O)C.CS(C)=O>[NH2:5][C:6]1[N:11]=[C:10]([OH:12])[C:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C:1]#[N:2])=[CH:16][CH:15]=2)=[C:8]([CH3:22])[N:7]=1

参加物

5

反応物 2

HCID 9032Potassium CyanideHCID 178433371HCID 178433371、化合物

生成物 1

HCID 178433372HCID 178433372、化合物

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 6228Dimethylformamide溶媒

実験手順

Potassium cyanide (2 g) was added to a solution of the product from step (ii) in DMF (20 ml) and DMSO (10 ml) and the mixture stirred at rt for 18 h. The mixture was flushed with nitrogen for 20 min, then diluted with brine (80 ml), stirred for 10 min and the precipitate filtered, washed with water then ether and dried to afford the subtitle compound, 2.46 g.

後処理

  1. customThe mixture was flushed with nitrogen for 20 min
  2. additiondiluted with brine (80 ml)
  3. stirringstirred for 10 min
  4. filtrationthe precipitate filtered
  5. washwashed with water
  6. dry with materialether and dried

出典と根拠

ORDレコード
ord-2ea4a16d71b64e6e97ad915f5099e11a
出典データセット
uspto-grants-2014_07
特許番号
US08765939B2

反応ノート

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