4-Methoxyphenylacetic Acid → 2-(3-((2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)-4-methoxyphenyl)acetic acid

HRID 1617218ノート

反応式

HRID 1617218 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9]O)=[C:4]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[N:3]=1.[CH3:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26]([OH:28])=[O:27])=[CH:21][CH:20]=1>Cl>[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][C:24]2[CH:23]=[C:22]([CH2:25][C:26]([OH:28])=[O:27])[CH:21]=[CH:20][C:19]=2[O:18][CH3:17])=[C:4]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[N:3]=1

参加物

4

反応物 2

HCID 76904-Methoxyphenylacetic AcidHCID 68418011(2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methanol

生成物 1

HCID 684129432-(3-((2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)-4-methoxyphenyl)acetic acid

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

To the product from step (iii) (0.8 g) in 1M aq HCl (20 ml), 4-methoxyphenylacetic acid (1.8 g) was added and heated under reflux for 48 h. The solvent was evaporated and the residue purified by SCX then by RPHPLC to give the subtitle compound, 164 mg.

後処理

  1. temperatureheated
  2. temperatureunder reflux for 48 h
  3. customThe solvent was evaporated
  4. customthe residue purified by SCX

出典と根拠

ORDレコード
ord-909add590cb04fffbac6c286ce2728b2
出典データセット
uspto-grants-2014_07
特許番号
US08765939B2

反応ノート

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