Ethanol → 2-(4-(2-Amino-4-(butylamino)-6-methylpyrimidin-5-ylthio)phenyl)acetic acid

HRID 1617258ノート

反応式

HRID 1617258 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([S:13][C:14]2[CH:19]=[CH:18][C:17](CC#N)=[CH:16][CH:15]=2)=[C:4]([CH3:23])[N:3]=1.[OH-:24].[K+].[CH3:26][CH2:27][OH:28]>>[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([S:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:26][C:27]([OH:24])=[O:28])=[CH:16][CH:15]=2)=[C:4]([CH3:23])[N:3]=1

参加物

4

反応物 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 684153862-(4-(2-Amino-4-(butylamino)-6-methylpyrimidin-5-ylthio)phenyl)acetonitrile

生成物 1

HCID 684157402-(4-(2-Amino-4-(butylamino)-6-methylpyrimidin-5-ylthio)phenyl)acetic acid

実験手順

A mixture of the product from step (v) (610 mg) and aq. 5M KOH (2 ml) in EtOH (8 ml) was heated under reflux for 18 h. The mixture was purified by RPHPLC to give the subtitle compound as a solid, 392 mg.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 18 h
  3. customThe mixture was purified by RPHPLC

出典と根拠

ORDレコード
ord-3a047b80770649eca06d0cd12a12f313
出典データセット
uspto-grants-2014_07
特許番号
US08765939B2

反応ノート

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