Lithium Chloride → Methyl 2-(5-bromo-3-nitropyridin-2-yl)acetate

HRID 1618506ノート

反応式

HRID 1618506 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([N+:17]([O-:19])=[O:18])[C:5]([CH:8](C(OC)=O)[C:9]([O:11][CH3:12])=[O:10])=[N:6][CH:7]=1.[Cl-].[Li+]>O>[Br:1][C:2]1[CH:3]=[C:4]([N+:17]([O-:19])=[O:18])[C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[N:6][CH:7]=1

参加物

4

反応物 2

HCID 433294Lithium ChlorideHCID 53217420Dimethyl 2-(5-bromo-3-nitropyridin-2-YL)malonate

生成物 1

HCID 67284396Methyl 2-(5-bromo-3-nitropyridin-2-yl)acetate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Prepared according to procedure H using dimethyl 2-(5-bromo-3-nitropyridin-2-yl)malonate (35 g, 105 mmol), lithium chloride (22.27 g, 525 mmol) and water (50 mL) and heating at reflux for 24 h. After purification methyl 2-(5-bromo-3-nitropyridin-2-yl)acetate was obtained as brown oil. Mass Spectrum (ESI) m/e=275 [(M+1) (79Br)] and 277 [(M+1) (81Br)].

後処理

  1. customPrepared
  2. temperatureheating
  3. temperatureat reflux for 24 h
  4. customAfter purification methyl 2-(5-bromo-3-nitropyridin-2-yl)acetate
  5. customwas obtained as brown oil

出典と根拠

ORDレコード
ord-85614c93c94a4551931fdc6ba25b9cb8
出典データセット
uspto-grants-2014_07
特許番号
US08765940B2

反応ノート

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