Hydrochloric Acid → 7-Fluoro-4-(6-iodo-3,3-dimethylindolin-1-yl)-3-methyl-2-(2-(methylsulfonyl)phenyl)quinoline

HRID 1618544ノート

反応式

HRID 1618544 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[S:19]([CH3:22])(=[O:21])=[O:20])[C:3]=1[CH3:23].[I:24][C:25]1[CH:33]=[C:32]2[C:28]([C:29]([CH3:35])([CH3:34])[CH2:30][NH:31]2)=[CH:27][CH:26]=1.Cl>CN1C(=O)CCC1>[F:12][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([N:31]3[C:32]4[C:28](=[CH:27][CH:26]=[C:25]([I:24])[CH:33]=4)[C:29]([CH3:35])([CH3:34])[CH2:30]3)=[C:3]([CH3:23])[C:4]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[S:19]([CH3:22])(=[O:21])=[O:20])=[N:5]2)=[CH:10][CH:9]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 582213076-Iodo-3,3-dimethylindolineHCID 672846274-Chloro-7-fluoro-3-methyl-2-(2-(methylsulfonyl)phenyl)quinoline

生成物 1

HCID 672849377-Fluoro-4-(6-iodo-3,3-dimethylindolin-1-yl)-3-methyl-2-(2-(methylsulfonyl)phenyl)quinoline

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

反応条件

温度
150 °C

実験手順

Prepared according to procedure L using 4-chloro-7-fluoro-3-methyl-2-(2-(methylsulfonyl)phenyl)quinoline (102 mg, 0.29 mmol) (described herein), 6-iodo-3,3-dimethylindoline (80 mg, 0.29 mmol) (described herein), hydrochloric acid (70 μL, 0.29 mmol), and NMP (0.490 mL). The reaction mixture was heated in a microwave at 150° C. for 150 min. Purification afforded 7-fluoro-4-(6-iodo-3,3-dimethylindolin-1-yl)-3-methyl-2-(2-(methylsulfonyl)phenyl)quinoline as a yellow solid. Mass Spectrum (ESI) m/e=587 (M+1).

後処理

  1. customPrepared
  2. customPurification

出典と根拠

ORDレコード
ord-2fcf5c62094f45e8b90971a4e115b994
出典データセット
uspto-grants-2014_07
特許番号
US08765940B2

反応ノート

読み込み中…