Aniline → HCID 178421928、化合物

反応式

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15](=O)[CH:16]([CH3:22])[C:17](OCC)=[O:18]>>[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[C:16]([CH3:22])=[C:17]([OH:18])[C:7]2[C:2](=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:1]=1

参加物

反応物 2

HCID 6115Aniline

HCID 67285418Ethyl 3-(2-fluorophenyl)-2-methyl-3-oxopropanoate

生成物 1

HCID 178421928HCID 178421928、化合物

実験手順

Prepared according to procedure R using aniline (0.91 mL, 10 mmol) and ethyl 3-(2-fluorophenyl)-2-methyl-3-oxopropanoate (4 g, 20 mmol) in PPA (4 g, 40 mmol). The resulting precipitate was collected by filtration, washed with water, and dried to give 2-(2-fluorophenyl)-3-methylquinolin-4-ol. Mass Spectrum (ESI) m/e=254 (M+1).

後処理

customPrepared
filtrationThe resulting precipitate was collected by filtration
washwashed with water
customdried

出典と根拠

ORDレコード: ord-bc77f94f99ef4ca6b437fc506cd0f3cf
出典データセット: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08765940B2

反応ノート

読み込み中…

参加物