2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl → 2-benzyl-4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-5,7-difluoro-3-methylquinoline

反応式

[CH2:1]([C:8]1[C:17]([CH3:18])=[C:16](Cl)[C:15]2[C:10](=[CH:11][C:12]([F:21])=[CH:13][C:14]=2[F:20])[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:22][C:23]1([CH3:38])[C:27]2=[N:28][CH:29]=[C:30]([N:32]3[CH2:37][CH2:36][O:35][CH2:34][CH2:33]3)[CH:31]=[C:26]2[NH:25][CH2:24]1.C1(P(C2CCCCC2)C2C=CC=CC=2C2C(C(C)C)=CC(C(C)C)=CC=2C(C)C)CCCCC1.CC(C)([O-])C.[Na+]>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].C1(C)C=CC=CC=1>[CH2:1]([C:8]1[C:17]([CH3:18])=[C:16]([N:25]2[C:26]3[C:27](=[N:28][CH:29]=[C:30]([N:32]4[CH2:33][CH2:34][O:35][CH2:36][CH2:37]4)[CH:31]=3)[C:23]([CH3:38])([CH3:22])[CH2:24]2)[C:15]2[C:10](=[CH:11][C:12]([F:21])=[CH:13][C:14]=2[F:20])[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1