Morpholine → 1-(5-fluoro-3-methyl-2-(2-pyridinyl)-4-quinolinyl)-7-(4-morpholinyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]-thiazine 4,4-dioxide

反応式

Cl[C:2]1[CH:31]=[N:30][C:5]2[S:6](=[O:29])(=[O:28])[CH2:7][CH2:8][N:9]([C:10]3[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][C:18]=4[F:20])[N:13]=[C:12]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=4)[C:11]=3[CH3:27])[C:4]=2[CH:3]=1.CC(C1C=C(C(C)C)C(C2C=CC=CC=2P(C2CCCCC2)C2CCCCC2)=C(C(C)C)C=1)C.[NH:66]1[CH2:71][CH2:70][O:69][CH2:68][CH2:67]1.CC(C)([O-])C.[Na+]>C1(C)C=CC=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[F:20][C:18]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:19]=1[C:10]([N:9]1[CH2:8][CH2:7][S:6](=[O:29])(=[O:28])[C:5]3[N:30]=[CH:31][C:2]([N:66]4[CH2:71][CH2:70][O:69][CH2:68][CH2:67]4)=[CH:3][C:4]1=3)=[C:11]([CH3:27])[C:12]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1)=[N:13]2