Potassium Carbonate → HCID 68289417、化合物

HRID 1618896ノート

反応式

HRID 1618896 の反応式
Br[C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[NH2:12][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[C:21]=1[C:20](=[O:22])[CH2:19][CH2:18]2.C(=O)([O-])[O-].[K+].[K+]>[Cu]I.CN1CCCC1=O>[N:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:11]=[C:2]([NH:12][C:13]2[CH:14]=[CH:15][CH:16]=[C:17]3[C:21]=2[C:20](=[O:22])[CH2:19][CH2:18]3)[CH:3]=1

参加物

6

反応物 3

HCID 11430Potassium CarbonateHCID 214133-BromoquinolineHCID 121192647-Amino-2,3-dihydro-1H-inden-1-one

生成物 1

HCID 68289417HCID 68289417、化合物収率 27.8%

試薬・触媒・溶媒 2

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)触媒HCID 13387N-methyl-2-pyrrolidone溶媒

反応条件

温度
200 °C

実験手順

0.43 g of 3-bromoquinoline, 0.29 g of 7-aminoindan-1-one, 0.08 g of copper (I) iodide, 0.41 g of potassium carbonate, and 4 ml of N-methylpyrrolidone were mixed, and then the mixture was stirred for 2 hours at 200° C. The resultant mixture was purified by silica gel column chromatography to obtain 0.15 g of 7-(quinolin-3-ylamino)-indan-1-one (Compound Number 50).

後処理

  1. customThe resultant mixture was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-5bbab0c577484f4a9d4d3257a1a0883c
出典データセット
uspto-grants-2014_07
特許番号
US08772200B2

反応ノート

読み込み中…