Water → (2-t-Butyl-phenyl)-(8-fluoro-quinolin-3-yl)-methanone

反応式

[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH:11]([C:13]1[CH:14]=[N:15][C:16]2[C:21]([CH:22]=1)=[CH:20][CH:19]=[CH:18][C:17]=2[F:23])[OH:12])([CH3:4])([CH3:3])[CH3:2].CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O.O>ClCCl>[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]([C:13]1[CH:14]=[N:15][C:16]2[C:21]([CH:22]=1)=[CH:20][CH:19]=[CH:18][C:17]=2[F:23])=[O:12])([CH3:4])([CH3:2])[CH3:3]

参加物

実験手順

After 0.32 g of (2-t-butyl-phenyl)-(8-fluoro-quinolin-3-yl)-methanol was dissolved in 3 ml of dichloromethane, 0.51 g of Dess-Martin reagent was added and the mixture was stirred for 1 hour at room temperature. After water was added and then the liquid was separated with ethyl acetate, the organic layer was concentrated and purified by silica gel column chromatography to obtain 0.21 g of (2-t-butyl-phenyl)-(8-fluoro-quinolin-3-yl)-methanone (Compound Number 57).