Potassium Carbonate → HCID 68288280、化合物
反応式
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][C:8]([OH:12])=[CH:7]2.[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16](F)[C:15]=1[I:21].C(=O)([O-])[O-].[K+].[K+]>CN1CCCC1=O>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][C:8]([O:12][C:16]1[CH:17]=[CH:18][CH:19]=[C:14]([F:13])[C:15]=1[I:21])=[CH:7]2参加物
5
反応条件
- 温度
- 130 °C
実験手順
16 ml of N-methylpyrrolidone was added to 1.06 g of 8-fluoro-3-hydroxyquinoline, 1.94 g of 2,6-difluoroiodobenzene, and 1.7 g of potassium carbonate, and the mixture was stirred for 24 hours at 130° C. The reaction solution was purified by silica gel column chromatography, and 0.55 g of 8-fluoro-3-(3-fluoro-2-iodophenoxy)-quinoline was obtained.
後処理
- customThe reaction solution was purified by silica gel column chromatography
出典と根拠
- ORDレコード
- ord-2fae9f307b6a449c9c0aa0b82ab1033c
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08772200B2
反応ノート
読み込み中…