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Oxalyl chloride → N-[(1-Butyl-4-piperidinyl)methyl]5-chloro-2-methylbenzoxazole-7-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 4-Aminomethyl-1-N-butylpiperidine | HCID 10442133 | — |
| 反応物 | 5-Chloro-2-methylbenzoxazole-7-carboxylic acid | HCID 19691864 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | N-[(1-Butyl-4-piperidinyl)methyl]5-chloro-2-methylbenzoxazole-7-carboxamide | HCID 19691850 | — |
反応手順
5-Chloro-2-methylbenzoxazole-7-carboxylic acid (Ger. Offen. 2,225,544) is converted to its acid chloride by treatment with oxalyl chloride. The acid chloride is treated with N-(1-butyl-4-piperidinyl)methylamine in the presence of triethylamine to afford the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05726187 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-6d542e3dbdd248a898a4ea74dbd0c2eb |
| 出典メモ | uspto-grants-1998_03 |