3,3-dibromo-6-chloro-1H,2H,3H-pyrrolo(3,2-c)pyridin-2-one → 6-Chloro-1,3-dihydro-2H-pyrrolo[3,2-c]pyridin-2-one
反応式
Br[C:2]1(Br)[C:6]2[CH:7]=[N:8][C:9]([Cl:11])=[CH:10][C:5]=2[NH:4][C:3]1=[O:12]>C(O)(=O)C.CO.[Zn]>[Cl:11][C:9]1[N:8]=[CH:7][C:6]2[CH2:2][C:3](=[O:12])[NH:4][C:5]=2[CH:10]=1参加物
5
実験手順
To a solution of 3,3-dibromo-6-chloro-1,3-dihydro-2H-pyrrolo[3,2-c]pyridin-2-one (preparation 36d, 1.14 g, 3.49 mmol) in acetic acid (35 mL) was added zinc dust (2.23 g, 34.10 mmol) in one portion and the mixture was stirred at room temperature for 50 minutes. The mixture was diluted with methanol and filtered through a fine frit. The filtrate was evaporated under reduced pressure and the residue was purified by flash chromatography (95:5 dichloromethane/methanol) to give the title compound (0.56 g, 91%) as a white solid.
後処理
- filtrationfiltered through a fine frit
- customThe filtrate was evaporated under reduced pressure
- customthe residue was purified by flash chromatography (95:5 dichloromethane/methanol)
出典と根拠
- ORDレコード
- ord-3399c7da341b47509f28ee7f1629f686
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08772288B2
反応ノート
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