Dimethylformamide dimethyl acetal → HCID 178425868、化合物
反応式
[I:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([NH2:7])=[O:6].CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>>[CH3:14][N:15](/[CH:17]=[N:7]/[C:5](=[O:6])[C:4]1[CH:8]=[CH:9][C:10]([CH3:11])=[C:2]([I:1])[CH:3]=1)[CH3:16]参加物
3
反応条件
- 温度
- 90 °C
実験手順
A suspension of 3-iodo-4-methylbenzamide (preparation 48a, 2.00 g, 7.7 mmol) in 1,1-dimethoxy-N,N-dimethylmethanamine (4.0 mL, 30.1 mmol) was heated in a sealed tube at 90° C. with stirring. After 2 hours, the mixture was cooled and concentrated in vacuo. The residue was triturated with diethyl ether and hexanes, and the solid that formed was filtered and dried to give the title compound (1.90 g, 78%) as a yellow solid.
後処理
- temperaturethe mixture was cooled
- concentrationconcentrated in vacuo
- customThe residue was triturated with diethyl ether and hexanes
- customthe solid that formed
- filtrationwas filtered
- customdried
出典と根拠
- ORDレコード
- ord-a96c8de0f841459bbe2e42d048a83120
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08772288B2
反応ノート
読み込み中…