1,3-Dimethyl 2-[(dimethylamino)methylidene]propanedioate → HCID 67257898、化合物
反応式
[CH3:1][N:2]([CH:4]=[C:5]([C:10]([O:12][CH3:13])=[O:11])[C:6]([O:8][CH3:9])=[O:7])C.[Br:14][C:15]1[CH:20]=C[N:18]=[C:17](N)[CH:16]=1>CC(O)=O.O>[Br:14][C:15]1[CH:16]=[CH:17][N:18]=[C:1]([NH:2][CH:4]=[C:5]([C:10]([O:12][CH3:13])=[O:11])[C:6]([O:8][CH3:9])=[O:7])[CH:20]=1参加物
5
実験手順
A solution of dimethyl 2-((dimethylamino)methylene)malonate (11.5 g, 65 mmol, 2.2 equiv) and 4-bromopyridin-2-amine (5 g, 28.9 mmol, 1 equiv) in AcOH (40 mL) was stirred at room temperature for 24 h. Then the reaction mixture was diluted with water, filtered, the filter cake was dried to give 4.8 g of the desired product. MS (ESI): 315, 317 (MH+).
後処理
- filtrationfiltered
- customthe filter cake was dried
出典と根拠
- ORDレコード
- ord-69cdfced59f44692aa96bf80d213db13
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08772301B2
反応ノート
読み込み中…