ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Hydrochloric Acid → 2-(4-(6-(4-(3-Isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-yloxy)phenyl)propane-1,3-diol

HRID 1619439
ノート
印刷プレビュー

反応式

HRID 1619439 の反応式
CC1(C)[O:7][CH2:6][CH:5]([C:8]2[CH:37]=[CH:36][C:11]([O:12][C:13]3[N:18]=[CH:17][N:16]=[C:15]([N:19]4[CH2:24][CH2:23][CH:22]([C:25]5[O:29][N:28]=[C:27]([CH:30]([CH3:32])[CH3:31])[N:26]=5)[CH2:21][CH2:20]4)[C:14]=3[N+:33]([O-:35])=[O:34])=[CH:10][CH:9]=2)[CH2:4][O:3]1.Cl>CC(C)=O>[CH:30]([C:27]1[N:26]=[C:25]([CH:22]2[CH2:21][CH2:20][N:19]([C:15]3[N:16]=[CH:17][N:18]=[C:13]([O:12][C:11]4[CH:36]=[CH:37][C:8]([CH:5]([CH2:6][OH:7])[CH2:4][OH:3])=[CH:9][CH:10]=4)[C:14]=3[N+:33]([O-:35])=[O:34])[CH2:24][CH2:23]2)[O:29][N:28]=1)([CH3:32])[CH3:31]
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 675155835-(1-(6-(4-(2,2-Dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole

生成物 1

HCID 675166662-(4-(6-(4-(3-Isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-yloxy)phenyl)propane-1,3-diol収率 5.4%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
27 °C

実験手順

To a solution of 5-(1-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole (500 mg, 0.0095 moles) in acetone (10 ml) was added conc. HCl (3 ml) and the reaction mixture was stirred for 4 hours at 27° C. The reaction mixture was concentrated and the residue was dissolved in ethyl acetate. The organic extract was successively washed with water & brine, dried over sodium sulfate and evaporated under reduced pressure to yield 250 mg product as yellow solid.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. extractionThe organic extract
  4. washwas successively washed with water & brine
  5. dry with materialdried over sodium sulfate
  6. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-2b149ae611a24626a9b7690305d5aaa4
出典データセット
uspto-grants-2014_07
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08772302B2

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート