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Hydrochloric Acid → (R)-Quinuclidin-3-yl 2-amino-2-phenylacetate dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | (R)-quinuclidin-3-yl 2-(tert-butoxycarbonylamino)-2-phenylacetate | HCID 67425060 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (R)-Quinuclidin-3-yl 2-amino-2-phenylacetate dihydrochloride | HCID 67425463 | 100.3% |
反応手順
To a solution of (R)-quinuclidin-3-yl 2-(tert-butoxycarbonylamino)-2-phenylacetate (C1) (1.25 g, 3.47 mmol) in THF (20 ml), was added 37% hydrogen chloride (2.00 ml, 24.3 mmol) dropwise. The reaction was stirred at RT for 15 hours. The solvent was evaporated to obtain (R)-quinuclidin-3-yl 2-amino-2-phenylacetate dihydrochloride (1.16 g; quantitative yield) as a solid. The compound was used in the next step without any further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08772314B2 |
| 出典データセット | uspto-grants-2014_07 |
| ORD ID | ord-2cbc7e4218c54fd884a503568f50ac5f |
| 出典メモ | uspto-grants-2014_07 |