化工社化工社 化学情報印刷レポート · 研究参考用
Cycloheptylamine → 1-Cycloheptyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cycloheptylamine | HCID 2899 | — |
| 反応物 | Dimethyl itaconate | HCID 69240 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 1-Cycloheptyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester | HCID 66656958 | — |
反応手順
A solution of dimethyl itaconate (0.5 g, 3.16 mmoles), cycloheptylamine (0.357 g, 3.16 mmoles) in methanol (5 mL) was heated at 85° C. for eighteen hours. The solvent was evaporated in vacuo and the resulting crude product was purified by flash chromatography (hexanes/ethyl acetate 80:20 to 20:80) to give the title compound as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737137B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-3d2c5d232e3848caaad5f18d300787d9 |
| 出典メモ | uspto-grants-2010_06 |