Acetyl chloride → (R)-3-methoxy-dihydro-furan-2,5-dione

反応式

[CH3:1][O:2][C@H:3]([CH2:7][C:8]([OH:10])=[O:9])[C:4]([OH:6])=O.C(Cl)(=O)C>>[CH3:1][O:2][C@@H:3]1[CH2:7][C:8](=[O:9])[O:10][C:4]1=[O:6]

参加物

反応物 2

HCID 6367Acetyl chloride

HCID 5325475(R)-methoxy-succinic acid

生成物 1

HCID 86689062(R)-3-methoxy-dihydro-furan-2,5-dione

実験手順

260 mg (1.76 mmol) (R)-methoxy-succinic acid are stirred together with 5 ml acetyl chloride for 2 days at RT, then the acetyl chloride is eliminated by rotary evaporation in vacuo.

後処理

customthe acetyl chloride is eliminated by rotary evaporation in vacuo

出典と根拠

ORDレコード: ord-19823be922e347f4a76b1f5ab5467e58
出典データセット: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08772323B2

反応ノート

読み込み中…