5-methyl-6-(2-thiophen-2-yl-benzoxazol-6-yl)-4,5-dihydro-2H-pyridazin-3-one → 5-methyl-6-(2-thiophen-2-yl-benzoxazol-6-yl)-2H-pyridazin-3-one
反応式
[CH3:1][CH:2]1[C:7]([C:8]2[CH:21]=[CH:20][C:11]3[N:12]=[C:13]([C:15]4[S:16][CH:17]=[CH:18][CH:19]=4)[O:14][C:10]=3[CH:9]=2)=[N:6][NH:5][C:4](=[O:22])[CH2:3]1>[O-2].[Mn+4].[O-2].O1CCOCC1>[CH3:1][C:2]1[C:7]([C:8]2[CH:21]=[CH:20][C:11]3[N:12]=[C:13]([C:15]4[S:16][CH:17]=[CH:18][CH:19]=4)[O:14][C:10]=3[CH:9]=2)=[N:6][NH:5][C:4](=[O:22])[CH:3]=1参加物
4
反応条件
- 温度
- 120 °C
実験手順
100 mg (321 μmol) 5-methyl-6-(2-thiophen-2-yl-benzoxazol-6-yl)-4,5-dihydro-2H-pyridazin-3-one, 0.08 mg (964 μmol) activated manganese(IV)oxide and 10 ml dioxane are combined and stirred overnight at 120° C. The reaction mixture is filtered through Celite, washed with DCM and EA and the solv. of the filtrate is eliminated i.V. The residue is recrystallised with DMF.