Methanol → 3-Bromo-2-methoxy-5-nitropyridine

HRID 1620102

反応式

HRID 1620102 の反応式
[CH3:1][O-:2].[Na+].CO.[Br:6][C:7]1[C:8](Cl)=[N:9][CH:10]=[C:11]([N+:13]([O-:15])=[O:14])[CH:12]=1>O>[Br:6][C:7]1[C:8]([O:2][CH3:1])=[N:9][CH:10]=[C:11]([N+:13]([O-:15])=[O:14])[CH:12]=1

参加物

5

反応物 3

HCID 887MethanolHCID 2308893-Bromo-2-chloro-5-nitropyridineHCID 10942334Sodium Methoxide

生成物 1

HCID 215844513-Bromo-2-methoxy-5-nitropyridine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Sodium methoxide (28% methanol solution) (2 ml) was added to a methanol (2 ml) solution containing 3-bromo-2-chloro-5-nitropyridine (100 mg), followed by stirring at room temperature for 1 hour. Water was added to the reaction solution, followed by extraction with ethyl acetate. The resultant was washed with saturated saline and dried over anhydrous sodium sulfate, the solvent was distilled away under reduced pressure, and a yellow solid of 3-bromo-2-methoxy-5-nitropyridine (96 mg) was thus obtained.

後処理

  1. extractionfollowed by extraction with ethyl acetate
  2. washThe resultant was washed with saturated saline
  3. dry with materialdried over anhydrous sodium sulfate
  4. distillationthe solvent was distilled away under reduced pressure

出典と根拠

ORDレコード
ord-06f9c9a52fc6457d8c66c3707e9dcc82
出典データセット
uspto-grants-2014_07
特許番号
US08772320B2

関連ノート

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