Hydrochloric Acid → methyl (S)-3-amino-2-piperidin-1-ylpropanoate dihydrochloride

HRID 1620377ノート

反応式

HRID 1620377 の反応式
C(OC([NH:8][CH2:9][C@H:10]([N:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[C:11]([O:13][CH3:14])=[O:12])=O)(C)(C)C.[ClH:21]>CO>[ClH:21].[ClH:21].[NH2:8][CH2:9][C@H:10]([N:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[C:11]([O:13][CH3:14])=[O:12]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 67056335methyl(S)-3-tert-butoxycarbonylamino-2-piperidin-1-ylpropanoate

生成物 1

HCID 67494635methyl (S)-3-amino-2-piperidin-1-ylpropanoate dihydrochloride収率 98%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
40 °C

実験手順

A solution of 750 mg (2.6 mmol) of methyl(S)-3-tert-butoxycarbonylamino-2-piperidin-1-ylpropanoate in 6 ml of methanol and 6 ml of isopropanolic hydrochloric acid, having a concentration of 5-6N, is stirred at 40° C. for 18 h. After concentration under vacuum, the residue is taken up in ethyl acetate, filtered and dried under vacuum. 670 mg (98%) of methyl(S)-3-amino-2-piperidin-1-ylpropanoate dihydrochloride are obtained in the form of a white solid.

後処理

  1. concentrationAfter concentration under vacuum
  2. filtrationfiltered
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-ffd2b19576874ea497829ff151111215
出典データセット
uspto-grants-2014_07
特許番号
US08772478B2

反応ノート

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