Hydrochloric Acid → methyl(S)-3-amino-2-morpholin-4-ylpropanoate hydrochloride
反応式
C(OC([NH:8][CH2:9][C@H:10]([N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)[C:11]([O:13][CH3:14])=[O:12])=O)(C)(C)C.[ClH:21]>CO.C(O)(C)C>[ClH:21].[NH2:8][CH2:9][C@H:10]([N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)[C:11]([O:13][CH3:14])=[O:12]参加物
5
反応条件
- 温度
- 40 °C
実験手順
A solution of 1.4 g (5 mmol) of methyl(S)-3-tert-butoxycarbonylamino-2-morpholin-4-ylpropanoate in 20 ml of methanol and 10 ml of a solution of hydrochloric acid having a 5-6N concentration in isopropanol is stirred at 40° C. for 20 h and then evaporated to dryness. 1.3 g (96%) of methyl(S)-3-amino-2-morpholin-4-ylpropanoate hydrochloride are obtained in the form of a solid.
後処理
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-ceae3ab955bb427a8ed948687938eb6c
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08772478B2
反応ノート
読み込み中…