Hydrogen chloride-ethyl acetate → HCID 178482469、化合物

HRID 1620468ノート

反応式

HRID 1620468 の反応式
[CH3:1][NH:2][C:3]1=[N:4][C:5](=[O:22])[S:6]/[C:7]/1=[CH:8]\[CH:9]1[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1.[ClH:23].C(OCC)(=O)C>O1CCCC1.CO>[ClH:23].[ClH:23].[CH3:1][NH:2][C:3]1=[N:4][C:5](=[O:22])[S:6]/[C:7]/1=[CH:8]\[CH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1

参加物

4

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178482474HCID 178482474、化合物

生成物 1

HCID 178482469HCID 178482469、化合物

試薬・触媒・溶媒 1

HCID 21899815MeOH tetrahydrofuran溶媒

反応条件

温度
80 °C

実験手順

To a solution of tert-butyl 4-{(Z)-[4-(methylamino)-2-oxo-1,3-thiazol-5(2H)-ylidene]methyl}piperidine-1-carboxylate (1.27 g) in tetrahydrofuran/methanol (6 mL/6 mL) was added 4M hydrogen chloride/ethyl acetate solution (5.85 mL), and the reaction mixture was stirred at 80° C. for 2 hr. The solvent was evaporated under reduced pressure, and the residue was washed with ethyl acetate to give the title compound (1.02 g).

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. washthe residue was washed with ethyl acetate

出典と根拠

ORDレコード
ord-3ee7f2a319124748babbb23808b54c5c
出典データセット
uspto-grants-2014_07
特許番号
US08772277B2

反応ノート

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