Hydrogen chloride-ethyl acetate → HCID 178456897、化合物

HRID 1620499

反応式

HRID 1620499 の反応式
[O:1]=[C:2]1[N:6]=[C:5]([NH:7][CH2:8][C:9]#[CH:10])/[C:4](=[CH:11]/[CH:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)/[S:3]1.[ClH:25].C(OCC)(=O)C>>[ClH:25].[ClH:25].[NH:15]1[CH2:16][CH2:17][CH:12](/[CH:11]=[C:4]2/[C:5]([NH:7][CH2:8][C:9]#[CH:10])=[N:6][C:2](=[O:1])[S:3]/2)[CH2:13][CH2:14]1

参加物

3

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178456946HCID 178456946、化合物

生成物 1

HCID 178456897HCID 178456897、化合物

実験手順

A mixed solution of tert-butyl 4-{(Z)-[2-oxo-4-(prop-2-yn-1-ylamino)-1,3-thiazol-5(2H)-ylidene]methyl}piperidine-1-carboxylate (14.0 g) and 4M hydrogen chloride/ethyl acetate solution (80 mL) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was washed with ethyl acetate to give the title compound (12.7 g).

後処理

  1. customthe solvent was evaporated under reduced pressure
  2. washThe residue was washed with ethyl acetate

出典と根拠

ORDレコード
ord-70343f03bc6e4b52a2f38fb43b3958f6
出典データセット
uspto-grants-2014_07
特許番号
US08772277B2

関連ノート

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