4-Sulfanylidene-1,3-thiazolidin-2-one → HCID 178518133、化合物

HRID 1620591ノート

反応式

HRID 1620591 の反応式
[CH:1]1([C:4]#[C:5][CH2:6][NH2:7])[CH2:3][CH2:2]1.S=[C:9]1[CH2:13][S:12][C:11](=[O:14])[NH:10]1>C(O)C>[CH:1]1([C:4]#[C:5][CH2:6][NH:7][C:9]2[CH2:13][S:12][C:11](=[O:14])[N:10]=2)[CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 15395954-Sulfanylidene-1,3-thiazolidin-2-oneHCID 22136558HCID 22136558、化合物

生成物 1

HCID 178518133HCID 178518133、化合物収率 88.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 3-cyclopropylprop-2-yn-1-amine (4.61 g) in ethanol (50 mL) was added 4-thioxo-1,3-thiazolidin-2-one (3.24 g), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated, and the residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) to give the title compound (4.20 g).

後処理

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane)

出典と根拠

ORDレコード
ord-04713f8530c647719b4a53a072a075d6
出典データセット
uspto-grants-2014_07
特許番号
US08772277B2

反応ノート

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