Hydrogen chloride-ethyl acetate → (3aR,6aS)-octahydrocyclopenta[c]pyrrol-5-ylmethanol hydrochloride
反応式
[OH:1][CH2:2][CH:3]1[CH2:17][C@@H:6]2[CH2:7][N:8](C(OC(C)(C)C)=O)[CH2:9][C@@H:5]2[CH2:4]1.[ClH:18].C(OCC)(=O)C>>[ClH:18].[CH2:7]1[C@H:6]2[CH2:17][CH:3]([CH2:2][OH:1])[CH2:4][C@H:5]2[CH2:9][NH:8]1参加物
3
実験手順
A solution of tert-butyl(3aR,6aS)-5-(hydroxymethyl)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate (2.24 g) (WO 2006/14325 A2, 2006) in 4N hydrogen chloride/ethyl acetate (10 mL) was stirred at room temperature for 1 hr. The reaction mixture was concentrated to give the title compound (1.65 g).
後処理
- concentrationThe reaction mixture was concentrated
出典と根拠
- ORDレコード
- ord-b8c310b1b81f48c5afb2a122eec8d63e
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08772277B2
反応ノート
読み込み中…