4-Sulfanylidene-1,3-thiazolidin-2-one → HCID 178484550、化合物
反応式
S=[C:2]1[CH2:6][S:5][C:4](=[O:7])[NH:3]1.Cl.[CH3:9][N:10]([CH3:16])[C:11](=[O:15])[CH2:12][CH2:13][NH2:14]>C(O)C>[CH3:9][N:10]([CH3:16])[C:11](=[O:15])[CH2:12][CH2:13][NH:14][C:2]1[CH2:6][S:5][C:4](=[O:7])[N:3]=1参加物
4
実験手順
To a solution of N,N-dimethyl-R-alaninamide (2.12 g) in ethanol (25 mL) was added 4-thioxo-1,3-thiazolidin-2-one (2.43 g), which N,N-dimethyl-β-alaninamide hydrochloride was treated with AMBERLYST (registered trademark) A21, and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated, and the residue was purified by silica gel column chromatography (NH, ethyl acetate/methanol) to give the title compound (0.33 g).
後処理
- additionwas treated with AMBERLYST (registered trademark) A21
- concentrationThe reaction mixture was concentrated
- customthe residue was purified by silica gel column chromatography (NH, ethyl acetate/methanol)
出典と根拠
- ORDレコード
- ord-da1ffbcf55f84ad19c2903de37d7f420
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08772277B2
反応ノート
読み込み中…