4-Sulfanylidene-1,3-thiazolidin-2-one → HCID 178496742、化合物

HRID 1620713ノート

反応式

HRID 1620713 の反応式
[CH3:1][N:2]([CH3:11])[C:3](=[O:10])[C@H:4]([C@@H:6]([CH3:9])[O:7][CH3:8])[NH2:5].S=[C:13]1[CH2:17][S:16][C:15](=[O:18])[NH:14]1>C(O)C>[CH3:11][N:2]([CH3:1])[C:3](=[O:10])[C@H:4]([C@@H:6]([CH3:9])[O:7][CH3:8])[NH:5][C:13]1[CH2:17][S:16][C:15](=[O:18])[N:14]=1

参加物

4

反応物 2

HCID 15395954-Sulfanylidene-1,3-thiazolidin-2-oneHCID 86678876(2S,3R)-2-amino-3-methoxy-N,N-dimethyl-butanamide

生成物 1

HCID 178496742HCID 178496742、化合物収率 35.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of N,N,O-trimethyl-L-threoninamide (1198 mg) in ethanol (10 mL) was added 4-thioxothiazolidin-2-one (996 mg) at room temperature. The reaction mixture was stirred at room temperature overnight, the solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) to give the title compound (680 mg).

後処理

  1. customthe solvent was evaporated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane)

出典と根拠

ORDレコード
ord-d7bce9d44053494ab92402ebe4a71ecc
出典データセット
uspto-grants-2014_07
特許番号
US08772277B2

反応ノート

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