4-Sulfanylidene-1,3-thiazolidin-2-one → HCID 178518185、化合物

HRID 1620724ノート

反応式

HRID 1620724 の反応式
[NH2:1][C@H:2]1[C@H:7]([OH:8])[CH2:6][O:5][CH2:4][CH2:3]1.S=[C:10]1[CH2:14][S:13][C:12](=[O:15])[NH:11]1>C(O)C>[O:15]=[C:12]1[N:11]=[C:10]([NH:1][C@H:2]2[C@H:7]([OH:8])[CH2:6][O:5][CH2:4][CH2:3]2)[CH2:14][S:13]1

参加物

4

反応物 2

HCID 15395954-Sulfanylidene-1,3-thiazolidin-2-oneHCID 54857363trans-4-Aminotetrahydropyran-3-ol

生成物 1

HCID 178518185HCID 178518185、化合物収率 40%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 3-amino-1,5-anhydro-2,3-dideoxy-threo-pentitol (3.20 g) in ethanol (100 mL) was added 4-thioxo-1,3-thiazolidin-2-one (3.63 g), and the mixture was heated under reflux overnight. The reaction mixture was filtered, the filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give the title compound (2.36 g).

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux overnight
  3. filtrationThe reaction mixture was filtered
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customthe residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether)

出典と根拠

ORDレコード
ord-69d1c4dd78ae46ef89d5de3501e7aa93
出典データセット
uspto-grants-2014_07
特許番号
US08772277B2

反応ノート

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