Triethylamine → HCID 178480330、化合物
反応式
Cl.[NH2:2][CH:3]1[CH2:8][CH2:7][CH2:6][N:5]([CH3:9])[C:4]1=[O:10].C(N(CC)CC)C.S=[C:19]1[CH2:23][S:22][C:21](=[O:24])[NH:20]1>C(O)C>[CH3:9][N:5]1[CH2:6][CH2:7][CH2:8][CH:3]([NH:2][C:19]2[CH2:23][S:22][C:21](=[O:24])[N:20]=2)[C:4]1=[O:10]参加物
5
実験手順
To a solution of the crude product containing 3-amino-1-methylpiperidin-2-one hydrochloride obtained in C) and triethylamine (3 mL) in ethanol (15 mL) was added 4-thioxothiazolidin-2-one (666 mg) at room temperature. The reaction mixture was stirred at room temperature overnight, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) to give the title compound (220 mg).
後処理
- customthe solvent was evaporated under reduced pressure
- customThe residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane)
出典と根拠
- ORDレコード
- ord-ecbfb4de05444bc3bcfdaa09aa7f967d
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08772277B2
反応ノート
読み込み中…