Potassium Hydroxide → (2S)-2-amino-4-fluoro-4-methylpentan-1-ol

To a solution of the fluoro derivative (21.0 g) from Step 4 in 90% aqueous ethyl alcohol (216 mL) was added potassium hydroxide (21.9 g). The mixture was heated at reflux for 4 hours and cooled to room temperature. The mixture was then concentrated and co-evaporated with toluene (3×300 mL). The residue was dissolved in dichloromethane (500 mL) and stirred for 0.5 hour. The suspension was filtered through celite and the celite was washed with dichloromethane (3×100 mL). The filtrate was concentrated to dryness to yield (2S)-2-amino-4-fluoro-4-methylpentan-1-ol.

1. temperatureThe mixture was heated
2. temperatureat reflux for 4 hours
3. concentrationThe mixture was then concentrated
4. dissolutionThe residue was dissolved in dichloromethane (500 mL)
5. filtrationThe suspension was filtered through celite
6. washthe celite was washed with dichloromethane (3×100 mL)
7. concentrationThe filtrate was concentrated to dryness

ORDレコード

ord-cf64790c0c06423a92afbecc01bf9b53

出典データセット

uspto-grants-2014_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08772336B2