Hydrochloric Acid → 2-(3-Phenyl-1H-1,2,4-triazol-1-yl)ethanamine dihydrochloride
反応式
[C:1]1([C:7]2[N:11]=[CH:10][N:9]([CH2:12][CH2:13][NH:14]C(=O)OC(C)(C)C)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:22]>O1CCOCC1>[ClH:22].[ClH:22].[C:1]1([C:7]2[N:11]=[CH:10][N:9]([CH2:12][CH2:13][NH2:14])[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1参加物
4
実験手順
To a solution of tert-butyl 2-(3-phenyl-1H-1,2,4-triazol-1-yl)ethylcarbamate (34 mg, 118 μmol) in dioxane (1 mL) was added hydrochloric acid (4M in dioxane, 590 μl, 2.36 mmol). The reaction mixture was stirred at RT for 18 h. All volatiles were removed in vacuo and the product was dried to yield a white solid (38 mg, 116 μmol, 98.7%) that was used without additional purification. MS: =189.3 M+H)+
後処理
- customAll volatiles were removed in vacuo
- customthe product was dried
出典と根拠
- ORDレコード
- ord-d5d56fc9526b44bfb6791e9d44abbbf4
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08772510B2
反応ノート
読み込み中…