Benzaldehyde → HCID 11807110、化合物

HRID 1621158ノート

反応式

HRID 1621158 の反応式
[CH:1](=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:9]/[N:10]=[C:11](\[CH3:20])/[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=O>Cl.O1CCOCC1>[CH3:20][C:11]1[N+:10]([O-:9])=[C:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[O:8][C:12]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

5

反応物 2

HCID 240BenzaldehydeHCID 95660631-Phenyl-1,2-propanedione-2-oxime

生成物 1

HCID 11807110HCID 11807110、化合物収率 51.7%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 312751,4-Dioxane溶媒

実験手順

To a solution of benzaldehyde (325 mg, 311 μL, 3.06 mmol) in HCl (4M in dioxane, 10 mL was added (E)-2-(hydroxyimino)-1-phenylpropan-1-one (500 mg, 3.06 mmol) at 0-5° C. The ice bath was removed and the mixture was stirred at RT for 24 h. All volatiles were removed and the residue was dissolved in HCl (4M in dioxane, 10 mL). The reaction mixture was stirred at RT for 6 h and concentrated. The obtained suspension was filtered, washed with diethyl ether and dried in vacuo to give the product as colorless solid (398 mg, 1.58 mmol, 51.7%).

後処理

  1. customThe ice bath was removed
  2. customAll volatiles were removed
  3. dissolutionthe residue was dissolved in HCl (4M in dioxane, 10 mL)
  4. stirringThe reaction mixture was stirred at RT for 6 h
  5. concentrationconcentrated
  6. filtrationThe obtained suspension was filtered
  7. washwashed with diethyl ether
  8. customdried in vacuo

出典と根拠

ORDレコード
ord-bfeeaac0ee914a47a3590a8951145700
出典データセット
uspto-grants-2014_07
特許番号
US08772510B2

反応ノート

読み込み中…