4-Fluorobenzaldehyde → 6-Fluoro-2-[(4-methoxyphenyl)methyl]isoquinolin-1-one

反応式

FC1C=CC(C=O)=CC=1.Cl[C:11]1[CH:20]=[C:19]2[C:14]([CH:15]=[CH:16][N:17]([CH2:22][C:23]3[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=3)[C:18]2=[O:21])=[CH:13][C:12]=1[F:31]>>[F:31][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:11]=1)[C:18](=[O:21])[N:17]([CH2:22][C:23]1[CH:24]=[CH:25][C:26]([O:29][CH3:30])=[CH:27][CH:28]=1)[CH:16]=[CH:15]2

参加物

反応物 2

HCID 680234-Fluorobenzaldehyde

HCID 598182477-Chloro-6-fluoro-2-[(4-methoxyphenyl)methyl]isoquinolin-1(2H)-one

生成物 1

HCID 598182606-Fluoro-2-[(4-methoxyphenyl)methyl]isoquinolin-1-one

実験手順

Starting from 4-fluoro benzaldehyde, the title compound was prepared following a similar sequence as described for 7-chloro-6-fluoro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one (62). Rt=1.72 min (Method B). Detected mass: 284.1 (M+H+).

出典と根拠

ORDレコード: ord-8aefff3168e546feb4473dd1e5cb1c9c
出典データセット: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08772492B2

反応ノート

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